When patients with respiratory tract infection need ventilator with nebulizing therapy,open system could easily leads to two problems:1. breathing circuit repeatedly assemble and disassemble causes the increases of exogenous infection problems. 2. breathing circuit interruption of ventilation may lead to alveoli collapse and potentially hinders efforts due to unbalance lung volume maintaining. In response to these two issues, through technical contradictions and physical contradiction induction to separate, flesible shells and isolating layers, beforehand cushioning, intermediary, cheap disposals, harmful changes into useful principles to solve exogenous infection and breathing circuit-caused by the sudden drop of respiratory tract pressure. In this paper, closed T-piece nebulize closed bolt design increased activity shutter control ventilator circuit to avoid the spread of infectious secretion and aerosol when connecting the nebulizer. Closed system to avoid atelectasis caused by the sudden drop of respiratory tract pressure when connecting the nebulizer. Keywords: TRIZ, Ventilator-induced lung injury, Acute respiratory distress syndrome,Healthcare-associated infection.